Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has
long been anticipated that our understanding of the basic principles of cell cycle control …

Drugs targeting the cell cycle–regulatory cyclin-dependent kinase (CDK) 4 and 6 have been
approved for the treatment of hormone receptor–positive breast cancer, and inhibitors …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Purpose To determine the clinical significance of flow cytometric minimal residual disease
(MRD) quantification in chronic lymphocytic leukemia (CLL) in addition to pretherapeutic risk …

Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK)
family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously …

Drugs for cancer therapy belong to different categories of chemical substances. The cellular
targets for the therapeutic efficacy are often not unambiguously identified. Here, we describe …