Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the
inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat …

Previous investigations have shown molecular cross-talk among activated adenosine
monophosphate-activated protein kinase (AMPK), proprotein convertase subtilisin/kexin …

Background Abnormalities in lipid and glucose metabolism are constantly observed in type
2 diabetes. However, these abnormalities can be ameliorated by polydatin. Considering the …

The link between insulin resistance (IR) and type 2 diabetes has been recognized for a long
time. Type 2 diabetes is often associated with basal hyperinsulinemia, reduced sensitivity to …

Objective Obesity induced metabolic dysregulation results in cluster of chronic conditions
mainly hyperglycemia, hyperinsulinemia, dyslipidemia, diabetes, cardiovascular …

The AMP-activated protein kinase (AMPK) is an evolutionary conserved and ubiquitously
expressed serine/threonine kinase mainly acting as a key regulator of cellular energy …

In recent years, obesity and diabetes have become the epidemic mainly due to fast food and
lifestyle changes. Several herbs have been claimed to control diabetes and obesity …

Drug resistance is becoming an obstacle in anti-cancer therapies. For target-based therapy
of lung cancer, gefitinib, as the first generation of tyrosine kinase inhibitors (TKIs) …

Mesenchymal stem cells are known for anti inflammatory and immunomodulatory activities.
The aim of our study was to evaluate the effect of human adipose derived mesenchymal …