Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Highlights•Malaria remains a killer disease and drug resistance poses a growing
problem.•Aminoacyl tRNA synthetases (aaRSs) are essential housekeeping …

Plasmodium falciparum Apicomplexan Apetala 2 Invasion (Pf AP2-I) transcription factor (TF)
is a protein that regulates the expression of a subset of gene families involved in P …

Background Treatment of parasitic diseases has been challenging due to evolution of drug
resistant parasites, and thus there is need to identify new class of drugs and drug targets …

Background Plasmodium falciparum is an obligate intracellular parasite of humans that
causes malaria. Falciparum malaria is a major public health threat to human life responsible …

Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan
phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and …

Malaria remains one of the most prevalent infectious diseases worldwide, primarily affecting
some of the most vulnerable populations around the globe. Despite achievements in the …

In the field of medicinal chemistry, the concept of pharmacophore refers to the specific
region of a molecule that possesses essential structural and chemical characteristics for …

Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of
novel drug targets and inhibitor molecules. The multi-component protein translation …

Introduction: Quinazolin-4 (3 H)-one derivatives have attracted considerable attention in the
pharmacological profiling of therapeutic drug targets. The present article reveals the …