Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …

Liver cancer remains a global health challenge with a projected incidence of over one
million cases by 2025. Hepatocellular carcinoma (HCC) is a common primary liver cancer …

Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular
and genetic heterogeneity, which makes it a challenging subject in terms of the underlying …

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of
each patient and reduce the toxicity caused by conventional antitumor strategies. It has been …

Tumor-associated macrophages (TAMs) are a type of functionally plastic immune cell
population in tumor microenvironment (TME) and mainly polarized into two phenotypes: M2 …

Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies. They are
characterized by a peculiar tumor microenvironment and dense vascularization. The …

Low response rates to immunotherapy have been reported in soft tissue sarcoma (STS).
There are few predictive biomarkers of response, and the tumor immune microenvironment …

Hepatic stellate cells (HSC) and hydrogen sulfide (H2S) both play important roles in the
development of hepatocellar carcinoma (HCC). Whereas, in the microenvironment of HCC …

Globally, hepatic cancer ranks fourth in terms of cancer-related mortality and is the sixth
most frequent kind of cancer. Around 80% of liver cancers are hepatocellular carcinomas …