Gene evolution has long been thought to be primarily driven by duplication and
rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes …

The rate and mechanism of protein sequence evolution have been central questions in
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …

Many genetic variants that influence phenotypes of interest are located outside of protein-
coding genes, yet existing methods for identifying such variants have poor predictive power …

Lack of a general matrix formula hampers implementation of the semi-partial correlation,
also known as part correlation, to the higher-order coefficient. This is because the higher …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …

Novel protein-coding genes can arise either through re-organization of pre-existing genes or
de novo,. Processes involving re-organization of pre-existing genes, notably after gene …

The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production
and degradation. Whereas the control of mRNA synthesis through transcription has been …

Gene duplication provides raw material for functional innovation. Recent advances have
shed light on two fundamental questions regarding gene duplication: which genes tend to …

Five decades have passed since the proposal of the molecular clock hypothesis, which
states that the rate of evolution at the molecular level is constant through time and among …

Comparative analysis of multiple genomes in a phylogenetic framework dramatically
improves the precision and sensitivity of evolutionary inference, producing more robust …