Asthma increases worldwide without any definite reason and patient numbers double every
10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but …

Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine
triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells …

ERK1/2 (extracellular signal-regulated kinases 1 and 2) regulate the activity of various
transcription factors that contribute to asthma pathogenesis. Although an attractive drug …

Vitamin A deficiency has been shown to exacerbate allergic asthma. Previous studies have
postulated that retinoic acid (RA), an active metabolite of vitamin A and high-affinity ligand …

Exposure to ionizing radiation results in injuries of the hematopoietic, gastrointestinal, and
respiratory systems, which are the leading causes responsible for morbidity and mortality …

High-dose radiation exposure results in organ-specific sequelae that occurs in a time-and
dose-dependent manner. The partial body irradiation with minimal bone marrow sparing …

Asthma is a chronic airway inflammatory disease in children characterized by airway
inflammation, airway hyperresponsiveness and airway remodeling. Childhood asthma is …

Highlights•Obstructive pulmonary disease is caused by inflammation.•Inflammatory signals
activate kinase signaling pathways.•Kinases regulate transcription factors that modulate the …

Background Defective absorption of acute allergic airway inflammation is involved in the
initiation and development of chronic asthma. After allergen exposure, there is a rapid …

Background Diacylglycerol kinase (DGK) regulates intracellular signaling and functions by
converting diacylglycerol (DAG) into phosphatidic acid. We previously demonstrated that …