Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …

Ulcerative colitis (UC) is one of the two forms of inflammatory bowel disease. It affects 5
million people globally, and is a chronic and recurring inflammation of the gastrointestinal …

We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with
infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin …

Integrin heterodimers containing an Integrin alpha V subunit are essential for development
and play critical roles in cell adhesion and signaling. We identified biallelic variants in the …

Background Inflammatory bowel disease (IBD) follows a heterogenous disease course and
predicting a patient's prognosis is challenging. There is a wide burden of illness in IBD and …

Background The possibility of preventing inflammatory bowel disease (IBD) is becoming
more plausible due to advances in understanding preclinical disease and successful …

Introduction Ulcerative colitis (UC) is a chronic illness requiring lifelong management that
could be enhanced by personalizing care using biomarkers. Areas covered The main …

11 Acknowledgement: We would like to thank the Helmsley Charitable Trust for their
generous 12 support of the PROMISE consortium (PRediction and PRevention through …

Inflammatory bowel diseases comprising Crohn's disease and ulcerative colitis have
emerged as global diseases. Multiple distinct therapeutic mechanisms have allowed us to …

Diagnosing inflammatory bowel disease (IBD) can often be challenging, and differentiating
between Crohn's disease and ulcerative colitis can be particularly difficult. Diagnostic …