Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract
Microtubules are generated at centrosomes, chromosomes, and within spindles during cell
division. Whereas microtubule nucleation at the centrosome is well characterized, much …
division. Whereas microtubule nucleation at the centrosome is well characterized, much …
Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
Correct mitotic spindle size is required for accurate chromosome segregation during cell
division. It is controlled by mechanical forces generated by molecular motors and non-motor …
division. It is controlled by mechanical forces generated by molecular motors and non-motor …
Force balance of opposing diffusive motors generates polarity-sorted microtubule patterns
C Utzschneider, B Suresh, A Sciortino… - Proceedings of the …, 2024 - pnas.org
The internal organization of cells is largely determined by the architecture and orientation of
the microtubule network. Microtubules serve as polar tracks for the selective transport of …
the microtubule network. Microtubules serve as polar tracks for the selective transport of …
Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors
Microtubules and molecular motors are essential components of the cellular cytoskeleton,
driving fundamental processes in vivo, including chromosome segregation and cargo …
driving fundamental processes in vivo, including chromosome segregation and cargo …
Effects of microtubule length and crowding on active microtubule network organization
Active filament networks can organize into various dynamic architectures driven by cross-
linking motors. Densities and kinetic properties of motors and microtubules have been …
linking motors. Densities and kinetic properties of motors and microtubules have been …
Kinesin-driven de-mixing of cytoskeleton composites drives emergent mechanical properties
J Sheung, C Gunter, K Matic, M Sasanpour… - arXiv preprint arXiv …, 2025 - arxiv.org
The cytoskeleton is an active composite of filamentous proteins that dictates diverse
mechanical properties and processes in eukaryotic cells by generating forces and …
mechanical properties and processes in eukaryotic cells by generating forces and …
Functional regulation of the mitotic kinesin HSET by Intraflagellar Transport proteins.
A Guesdon, V Simon, J Van Dijk, B Delaval, B Vitre - bioRxiv, 2025 - biorxiv.org
HSET is a mitotic kinesin essential for centrosome clustering in cells harboring
supernumerary centrosomes. Previous work in cellulo revealed a physical and functional …
supernumerary centrosomes. Previous work in cellulo revealed a physical and functional …