The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

Many genetic and environmental factors increase susceptibility to cognitive impairment (CI),
and the gut microbiome is increasingly implicated. However, the identity of gut microbes …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …

Background Cognitive manifestations associated with Severe Acute Respiratory Syndrome
by Coronavirus 2 (SARS-CoV-2) are yet to be described in the existing literature. The aim of …

Abstract Alzheimer's disease (AD), is a neurodegenerative disorder that escalates with time,
exerting a significant impact on physical and mental health and leading to death. The …

The aim of this study was to explore the therapeutic effect and underling mechanism of
Dendrobium officinale polysaccharides (DOPS) on two well-established animal models of …

Rationale: Sepsis causes brain dysfunction and neuroinflammation. It is unknown whether
neuroinflammation in sepsis is initiated by dissemination of bacteria to the brain and …

Chronic hypoxia is considered as one of the important environmental factors contributing to
the pathogenesis of Alzheimer's disease (AD). Many chronic hypoxia-causing comorbidities …

The discovery of biomarkers for Parkinson's disease (PD) is challenging due to the
heterogeneous nature of this disorder, and a poor correlation between the underlying …