The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy
S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
Controlling natural killer cell responses: integration of signals for activation and inhibition
Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …
in the absence of antigen-specific receptors has been a challenge, but recent work has …
Functions of natural killer cells
E Vivier, E Tomasello, M Baratin, T Walzer… - Nature …, 2008 - nature.com
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …
several types of tumors and microbial infections by limiting their spread and subsequent …
NK cell receptors
LL Lanier - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …
effector function. While positive stimulation may be initiated by an array of co-stimulatory …
[HTML][HTML] Natural killer cell education and tolerance
MT Orr, LL Lanier - Cell, 2010 - cell.com
Natural killer (NK) cells play a key role in the immune response to certain infections and
malignancies by direct cytolysis of infected or transformed cells and by secretion of potent …
malignancies by direct cytolysis of infected or transformed cells and by secretion of potent …
Natural killer cell education and the response to infection and cancer therapy: stay tuned
JE Boudreau, KC Hsu - Trends in immunology, 2018 - cell.com
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
Self-tolerance of natural killer cells
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means
that NK cells have the potential to attack normal self cells but that there are mechanisms to …
that NK cells have the potential to attack normal self cells but that there are mechanisms to …
Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value.
L Ruggeri, A Mancusi, M Capanni… - Blood, The Journal …, 2007 - ashpublications.org
We analyzed 112 patients with high-risk acute myeloid leukemia (61 in complete remission
[CR]; 51 in relapse), who received human leukocyte-antigen (HLA)–haploidentical …
[CR]; 51 in relapse), who received human leukocyte-antigen (HLA)–haploidentical …
Regulation of immune responses through inhibitory receptors
EO Long - Annual review of immunology, 1999 - annualreviews.org
▪ Abstract Major histocompatibility complex class I-specific inhibitory receptors on natural
killer cells prevent the lysis of healthy autologous cells. The outcome of this negative signal …
killer cells prevent the lysis of healthy autologous cells. The outcome of this negative signal …
A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules
It is widely believed that self-tolerance of natural killer (NK) cells occurs because each NK
cell expresses at least one inhibitory receptor specific for a host major histocompatibility …
cell expresses at least one inhibitory receptor specific for a host major histocompatibility …