Frontiers in the treatment of glioblastoma: Past, present and emerging

TI Janjua, P Rewatkar, A Ahmed-Cox, I Saeed… - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Physics of brain cancer: Multiscale alterations of glioblastoma cells under extracellular matrix stiffening

M Khoonkari, D Liang, M Kamperman, FAE Kruyt… - Pharmaceutics, 2022 - mdpi.com
The biology and physics underlying glioblastoma is not yet completely understood, resulting
in the limited efficacy of current clinical therapy. Recent studies have indicated the …

Charge conversional biomimetic nanocomplexes as a multifunctional platform for boosting orthotopic glioblastoma RNAi therapy

Y Liu, Y Zou, C Feng, A Lee, J Yin, R Chung… - Nano …, 2020 - ACS Publications
Nanotechnology-based RNA interference (RNAi) has shown great promise in overcoming
the limitations of traditional clinical treatments for glioblastoma (GBM). However, because of …

Perspective of point-of-care sensing system in cancer management

KR Khondakar, MS Anwar, H Mazumdar… - Materials …, 2023 - pubs.rsc.org
Globally, the number of cancer cases is rising, with no difference between rich and
undeveloped countries. Although affluent nations have made great improvements in the …

Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application

Z Wang, Y Zhang, Z Li, H Wang, N Li, Y Deng - Small, 2023 - Wiley Online Library
As an ideal in vitro model, brain‐on‐chip (BoC) is an important tool to comprehensively
elucidate brain characteristics. However, the in vitro model for the definition scope of BoC …

Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation

A Soubéran, A Tchoghandjian - Cancers, 2020 - mdpi.com
Fifteen years after the establishment of the Stupp protocol as the standard of care to treat
glioblastomas, no major clinical advances have been achieved and increasing patient's …

DDRugging glioblastoma: Understanding and targeting the DNA damage response to improve future therapies

O Rominiyi, SJ Collis - Molecular Oncology, 2022 - Wiley Online Library
Glioblastoma is the most frequently diagnosed type of primary brain tumour in adults. These
aggressive tumours are characterised by inherent treatment resistance and disease …

Inorganic nanomaterial for biomedical imaging of brain diseases

W Du, L Zhou, Q Zhang, X Liu, X Wei, Y Li - Molecules, 2021 - mdpi.com
In the past few decades, brain diseases have taken a heavy toll on human health and social
systems. Magnetic resonance imaging (MRI), photoacoustic imaging (PA), computed …

Cancer cell direct bioprinting: A focused review

DA Lobo, P Ginestra, E Ceretti, TP Miquel, J Ciurana - Micromachines, 2021 - mdpi.com
Three-dimensional printing technologies allow for the fabrication of complex parts with
accurate geometry and less production time. When applied to biomedical applications, two …

Microvalve bioprinting as a biofabrication tool to decipher tumor and endothelial cell crosstalk: Application to a simplified glioblastoma model

N Dusserre, ML Stachowicz, C Medina, B Henri… - Bioprinting, 2021 - Elsevier
Bioprinting technologies are powerful new bioengineering tools that can spatially reproduce
multiple microenvironmental cues in a highly controlled, tunable, and precise manner. In this …