Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Understanding the functions of proteins requires information about their protein-protein
interactions (PPI). The collective effort of the scientific community generates far more data on …

The clinical use of classical glucocorticoids (GC) is narrowed by the many side effects it
causes and the resistance to GC observed in some diseases. Since the great majority of GC …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

Hsp90 is an essential molecular chaperone responsible for the folding and activation of
hundreds of 'client'proteins, including the glucocorticoid receptor (GR). Previously, we …

In this article we summarize the birth of the field of nuclear receptors, the discovery of
untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …