Molecular pathways governing the termination of liver regeneration

LR de Haan, RF van Golen, M Heger, M Michel - Pharmacological reviews, 2024 - Elsevier
The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed
without detrimental consequences to the organism. Liver regeneration is a complex process …

Ferroptosis-based therapeutic strategies toward precision medicine for cancer

TM Shi, XF Chen, H Ti - Journal of Medicinal Chemistry, 2024 - ACS Publications
Ferroptosis is a type of iron-dependent programmed cell death characterized by the
dysregulation of iron metabolism and the accumulation of lipid peroxides. This nonapoptotic …

Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox …

LR de Haan, MJ Reiniers, LF Reeskamp, A Belkouz… - Antioxidants, 2022 - mdpi.com
Oxidative stress has been causally linked to various diseases. Electron transport chain
(ETC) inhibitors such as rotenone and antimycin A are frequently used in model systems to …

Unravelling bisphenol A-induced hepatotoxicity: Insights into oxidative stress, inflammation, and energy dysregulation

S Das, U Mukherjee, S Biswas, S Banerjee… - Environmental …, 2024 - Elsevier
Bisphenol A (BPA), a prevalent plastic monomer and endocrine disruptor, negatively
impacts metabolic functions. This study examines the chronic effects of eco-relevant BPA …

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

P Sitarek, T Kowalczyk, E Synowiec… - Cells, 2022 - mdpi.com
Plectranthus ornatus Codd, the genus Plectranthus of the Lamiaceae family, has been used
as traditional medicine in Africa, India and Australia. Pharmacological studies show the use …

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

MR Mollaeva, E Nikolskaya, V Beganovskaya, M Sokol… - Antioxidants, 2021 - mdpi.com
Pheophorbide a 17-diethylene glycol ester (XL-8), is a promising high-active derivative of
known photosensitizer chlorin e6 used in photodynamic therapy. However, high lipophilicity …

Increased radical scavenging activity of thymoquinone and l-ascorbic acid dual encapsulated in palmitoyl-chitosan nanoparticles in a human normal lung fibroblast …

N Othman, SNAM Jamil, MJ Masarudin, RABM Jusoh… - RSC …, 2023 - pubs.rsc.org
Less effective antioxidant supplementation in combating free radicals is often related to the
lack of the formulation of carriers. The antioxidant may be one of the most powerful …

Anti-hyperglycemic contours of Madhugrit are robustly translated in the Caenorhabditis elegans model of lipid accumulation by regulating oxidative stress and …

A Balkrishna, V Gohel, N Pathak, M Tomer… - Frontiers in …, 2022 - frontiersin.org
Background The prevalence of diabetes has considerably increased in recent years. In the
long run, use of dual therapy of anti-diabetic agents becomes mandatory to attain …

[HTML][HTML] Improving the dichloro-dihydro-fluorescein (DCFH) assay for the assessment of intracellular reactive oxygen species formation by nanomaterials

N Ruijter, M van der Zee, A Katsumiti, M Boyles… - NanoImpact, 2024 - Elsevier
Abstract To facilitate Safe and Sustainable by Design (SSbD) strategies during the
development of nanomaterials (NMs), quick and easy in vitro assays to test for hazard …

Enhancement of 5-Aminolevulinic Acid-Mediated Photodynamic Inactivation of Proteus mirabilis Using Phosphoric and Bisaminophosphinic Acids as Permeabilizing …

A Zdubek, I Maliszewska, A Grabowiecka… - ACS …, 2024 - ACS Publications
The purpose of this work was to examine the effect of phosphoric and bisaminophosphinic
acids on the effectiveness of photoinactivation of Proteus mirabilis with 5-aminolevulinic acid …