We present an update and revision to our 2010 review on the topic of proton-coupled
electron transfer (PCET) reagent thermochemistry. Over the past decade, the data and …

The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The selective functionalization of alkanes has long been recognized as a prominent
challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) …

Thiyl radicals have been used by nature in a broad range of biochemical processes. For
instance, thiol residues play an important role in many enzymatic processes as illustrated by …

Many, if not most, redox reactions are coupled to proton transfers. This includes most
common sources of chemical potential energy, from the bioenergetic processes that power …

Understanding the energy it takes to build or break chemical bonds is essential for scientists
and engineers in a wide range of innovative fields, including catalysis, nanomaterials …

Otherwise sluggish or completely ineffective radical reductions of alkyl and aryl halides by N-
heterocyclic carbene boranes (NHC-boranes) are catalyzed by thiols. Reductions and …

Radical hydrogenation via hydrogen atom transfer (HAT) to alkenes is an increasingly
important transformation for the formation of thermodynamic alkane isomers. Current single …

Hydropersulfides (RSSH) are formed endogenously via the reaction of the gaseous
biotransmitter hydrogen sulfide (H2S) and disulfides (RSSR) and/or sulfenic acids (RSOH) …

Composite ab initio CBS-Q and G3 methods were used to calculate the bond dissociation
energies (BDEs) of over 200 compounds listed in CRC Handbook of Chemistry and Physics …