Background Recently there has been an increase in Candida infections worldwide. A
handful of species in the genus Candida are opportunistic pathogens and have been known …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …

Definition Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by
stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal) …

The worldwide emergence of multidrug-resistant pathogenic fungi is a threat to human
health. At this very moment, an emergence of Candida parapsilosis isolates harboring a …

Resistance to antifungal drugs is an increasingly significant clinical problem. The most
common antifungal resistance encountered is efflux pump-mediated resistance of Candida …

Drug resistance in Candida species has been considerably increased in the last decades.
Given the opposition to antifungal agents, toxicity and interactions of the antimicrobial drugs …

Invasive candidiasis (IC) has emerged in the last decades as an important cause of
morbidity, mortality, and economic load in the intensive care unit (ICU). The epidemiology of …

Objectives The aim of this study was to determine how mutations in CpERG11 and CpTAC1
contribute to fluconazole resistance in a collection of clinical isolates. Methods Sequences of …

Background Antifungal resistance rates are increasing. We investigated the mechanisms of
azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study …