Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key roles in excitatory synaptic …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

Most excitatory synapses in the brain use the neurotransmitter glutamate to carry impulses
between neurons. During fast transmission, glutamate usually activates a mixture of N …

NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits …

N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

Dopamine neurons in the ventral tegmental area (VTA) represent a critical site of synaptic
plasticity induced by addictive drugs. Orexin/hypocretin-containing neurons in the lateral …

This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …