Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

HH Heng, SW Bremer, JB Stevens, SD Horne… - Cancer and Metastasis …, 2013 - Springer
Results of various cancer genome sequencing projects have “unexpectedly” challenged the
framework of the current somatic gene mutation theory of cancer. The prevalence of diverse …

The elephant in the room: The role of microtubules in cancer

L Cirillo, M Gotta, P Meraldi - Cell Division Machinery and Disease, 2017 - Springer
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour
constitutes the basis for many biological processes such as cellular motility, cytoplasmic …

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

S Duffy, HK Fam, YK Wang, EB Styles… - Proceedings of the …, 2016 - National Acad Sciences
Somatic copy number amplification and gene overexpression are common features of many
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …

[HTML][HTML] Chromosomal instability and acquired drug resistance in multiple myeloma

W Wang, Y Zhang, R Chen, Z Tian, Y Zhai, S Janz… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Chromosomal instability (CIN) is an important hallmark of human cancer. CIN not only
contributes to all stages of tumor development (initiation, promotion and progression) but …

E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

W Zhang, CHL Yeung, L Wu, KWY Yuen - Elife, 2017 - elifesciences.org
Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its
interacting partner Lge1, are responsible for histone H2B monoubiquitination, which …

Nondysplastic ulcerative colitis has high levels of the homologous recombination repair protein NUCKS1 and low levels of the DNA damage marker gamma-H2AX

PM De Angelis, AR Schjølberg… - Inflammatory Bowel …, 2018 - academic.oup.com
Background The colon and rectum are continuously exposed to oxidative stress that
generates reactive oxygen species, which are a major cause of DNA double-strand breaks …

Причина раковых мутаций: поправимая плохая жизнь или неизбежные стохастические ошибки репликации?

ИВ Алексеенко, АИ Кузьмич, ВВ Плешкан… - Молекулярная …, 2016 - elibrary.ru
Несмотря на значительные успехи, достигнутые в понимании механизмов онкогенеза
и, как следствие, в борьбе с онкологическими заболеваниями, смертность от них …

Genomic Instability in Colorectal Adenomas with and without Recurrence

D Fiedler - 2019 - archiv.ub.uni-heidelberg.de
Colorectal adenomas are precursors to colorectal cancer, one of the most common types of
cancer diagnosed in both men and women in the Western world. Therefore, endoscopic …

[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Overexpression screens identify conserved dosage chromosome instability genes in yeast …

S Duffy, HK Fam, YK Wang, EB Styles… - Proceedings of the …, 2016 - ncbi.nlm.nih.gov
Genes. To discover genes that when overexpressed result in CIN, we screened an arrayed
collection of 5,100 yeast strains, each conditionally overexpressing a unique gene under the …

[图书][B] The Spindle Assembly Checkpoint-A Predictor of Anthracycline Sensitivity in Breast Cancer Patients

M Al-waadh - 2016 - search.proquest.com
Identifying drug response remains a major challenge in breast cancer patients treated with
adjuvant chemotherapy, as some patients relapse following treatment. Breast cancer …