Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays
important roles in host defense and oxidative biosynthetic reactions. In addition there is …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …

Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging
peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from …

H 2 O 2 acts as a signaling molecule by oxidizing critical thiol groups on redox-regulated
target proteins. To explain the efficiency and selectivity of H 2 O 2-based signaling, it has …

Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …

Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …