Contemporary biological insights and clinical management of craniopharyngioma

JR Apps, HL Muller, TC Hankinson, TI Yock… - Endocrine …, 2023 - academic.oup.com
Craniopharyngiomas (CPs) are clinically aggressive tumors because of their invasive
behavior and recalcitrant tendency to recur after therapy. There are 2 types based on their …

BRAF mutations and the utility of RAF and MEK inhibitors in primary brain tumors

KC Schreck, SA Grossman, CA Pratilas - Cancers, 2019 - mdpi.com
BRAF mutations have been identified as targetable, oncogenic mutations in many cancers.
Given the paucity of treatments for primary brain tumors and the poor prognosis associated …

[HTML][HTML] BRAF–MEK inhibition in newly diagnosed papillary Craniopharyngiomas

PK Brastianos, E Twohy, S Geyer… - … England Journal of …, 2023 - Mass Medical Soc
Background Craniopharyngiomas, primary brain tumors of the pituitary–hypothalamic axis,
can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or …

Childhood-onset craniopharyngioma

A Otte, HL Müller - The Journal of Clinical Endocrinology & …, 2021 - academic.oup.com
Craniopharyngiomas are rare embryonic malformational tumors of the sellar/parasellar
region, classified by the World Health Organization (WHO) as tumors with low-grade …

Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations

TA Juratli, PS Jones, N Wang, M Subramanian… - Cancer, 2019 - Wiley Online Library
Papillary craniopharyngiomas (PCPs) are characterized by the presence of BRAF V600E
mutations, which are emerging as a useful guide for diagnosis and treatment decision …

Endocrine disorder in patients with craniopharyngioma

Z Zhou, S Zhang, F Hu - Frontiers in neurology, 2021 - frontiersin.org
Craniopharyngioma is an intracranial congenital epithelial tumor growing along the pathway
of the embryonic craniopharyngeal tube. The main clinical symptoms of patients with …

Craniopharyngioma—an update on metabolic and cognitive complications and new therapy

EM Erfurth - Journal of Internal Medicine, 2023 - Wiley Online Library
Craniopharyngiomas (CPs) are rare primary brain epithelial tumors arising in the suprasellar
region from remnants of Rathke's pouch. About 50% originate at the level of the third …

Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up

A Bogusz, HL Müller - Expert review of neurotherapeutics, 2018 - Taylor & Francis
Introduction: Childhood-onset craniopharyngiomas are rare embryonic tumors of low-grade
histological malignancy. Severe obesity, physical fatigue, and psychosocial deficits due to …

Neoadjuvant B-RAF and MEK inhibitor targeted therapy for adult papillary craniopharyngiomas: a new treatment paradigm

F Calvanese, T Jacquesson, R Manet… - Frontiers in …, 2022 - frontiersin.org
Background Surgical and clinical management of craniopharyngiomas is associated with
high long-term morbidity especially in the case of hypothalamic involvement. Improvements …

Advances in the management of craniopharyngioma in children and adults

M Jensterle, S Jazbinsek, R Bosnjak… - Radiology and …, 2019 - sciendo.com
Background. Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of
the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor …