Cancer cells require a robust supply of reduced nitrogen to produce nucleotides, non-
essential amino acids and a high cellular redox activity. Glutamine provides a major …

Cancer is an inevitable matter of concern in the medicinal chemistry era. Chalcone is the
well exploited scaffold in the anticancer domain. The molecular mechanism of chalcone at …

Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive
spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory …

Tuberculosis (TB) is a major infectious disease caused by Mycobacterium tuberculosis
(Mtb). According to the World Health Organization (WHO), about 1.8 million people die from …

Breast cancer is currently the most commonly diagnosed cancer, with 287,850 new cases
estimated for 2022 as reported by the American Cancer Society. Therefore, finding an …

Introduction: Chalcones are a group of plant-derived polyphenolic compounds belonging to
the flavonoids family that possess a wide variety of cytoprotective and modulatory functions …

We report herein, first ever synthesis of series of novel differently substituted quinoxalinyl
chalcones using Claisen Schmidt condensation, its molecular docking studies, and potential …

A silver-catalyzed double-decarboxylative protocol has been proposed for the construction
of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids …

Chalcones, naturally occurring open-chain flavonoids abundant in plants, have
demonstrated anticancer activity in multiple tumor cells. In a previous work, the potential …

Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers
worldwide. Chemoprevention of HCC can be achieved through the use of natural or …