Practically any stimulus capable of causing injury to a tissue or organ can, when applied
close to (but below) the threshold of damage, activate endogenous protective mechanisms …

In the last few years, there has been increasing interest in the physiological role of acylation-
stimulating protein (ASP). Recent studies in rats and mice, in particular in C3 (−/−) mice that …

Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as
ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an …

Background and Purpose—Cellular response to hypoxia is mainly controlled by hypoxia-
inducible factor 1 (HIF-1). The HIF-1 target gene erythropoietin (EPO) has been described as …

Hypoxic preconditioning (8% O 2, 3 h) produces tolerance 24 h after hypoxic-ischemic brain
injury in neonatal rats. To better understand the ischemic tolerance mechanisms induced by …

Background/purpose: Insufficient microcirculation of skin leads to acute and chronic tissue
ischemia in cases of trauma, reconstructive surgery, diabetes mellitus and peripheral arterial …

Acute cerebral ischemia occurs after subarachnoid hemorrhage (SAH) because of
increased intracranial pressure (ICP) and decreased cerebral perfusion pressure (CPP) …

The widely prescribed drug desferrioxamine is a known activator of the hypoxia-inducible
transcription factor 1 (HIF-1) and the subsequent transcription of erythropoietin. In the brain …

Cardiopulmonary arrest is one of the leading causes of death and disability, primarily
occurring in the aged population. Numerous global cerebral ischemia animal models induce …