Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Intraarticular ligament degeneration is interrelated with cartilage and bone destruction in osteoarthritis

G Schulze-Tanzil - Cells, 2019 - mdpi.com
Osteoarthritis (OA) induces inflammation and degeneration of all joint components including
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …

[HTML][HTML] Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years

MHJ van den Bosch, AB Blom… - Osteoarthritis and …, 2024 - Elsevier
Inflammation, both locally in the joint and systemic, is nowadays considered among the
mechanisms involved in osteoarthritis (OA). However, this concept has not always been …

[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration

Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

[HTML][HTML] Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and …

X Ji, Z Lei, M Yuan, H Zhu, X Yuan, W Liu, H Pu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment
strategy, but the poor mechanical properties and limited understanding of the interactions …

Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8

K Norimatsu, K Nakanishi, T Ijuin, S Otsuka… - Arthritis Research & …, 2023 - Springer
Background Osteoarthritis (OA) is a degenerative joint disease associated with aging, which
often leads to joint stiffness and disability. Exercise is one of the most important non …

[HTML][HTML] The difference in joint instability affects the onset of cartilage degeneration or subchondral bone changes

K Arakawa, K Takahata, S Enomoto, Y Oka… - Osteoarthritis and …, 2022 - Elsevier
Objective It has been debated whether the onset of knee osteoarthritis is initiated in cartilage
or subchondral bone. The purpose of this study was to clarify the effects of increasing or …

The roles of Indian hedgehog signaling in TMJ formation

TE Bechtold, N Kurio, HD Nah, C Saunders… - International journal of …, 2019 - mdpi.com
The temporomandibular joint (TMJ) is an intricate structure composed of the mandibular
condyle, articular disc, and glenoid fossa in the temporal bone. Apical condylar cartilage is …

Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre-and early-stage osteoarthritis in a rodent model

I Takahashi, K Takeda, T Toyama, T Matsuzaki… - Scientific Reports, 2024 - nature.com
Early diagnosis and treatment of pre-and early-stage osteoarthritis (OA) is important.
However, the cellular and cartilaginous changes occurring during these stages remain …

[HTML][HTML] Effects of exercise therapy on joint instability in patients with osteoarthritis of the knee: A systematic review

S Kawabata, K Murata, K Nakao, M Sonoo… - … and Cartilage Open, 2020 - Elsevier
Objective Abnormal load stress caused by joint instability has been reported to be one of the
factors responsible for the development of osteoarthritis (OA). However, few studies have …