Role of fibrinolytic enzymes in anti-thrombosis therapy

F Altaf, S Wu, V Kasim - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Thrombosis, a major cause of deaths in this modern era responsible for 31% of all global
deaths reported by WHO in 2017, is due to the aggregation of fibrin in blood vessels which …

Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: a comprehensive review

AMM Ali, SCB Bavisetty - International Journal of Biological …, 2020 - Elsevier
Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

Recent advances in nattokinase-enriched fermented soybean Foods: A review

D Li, L Hou, M Hu, Y Gao, Z Tian, B Fan, S Li, F Wang - Foods, 2022 - mdpi.com
With the dramatic increase in mortality of cardiovascular diseases (CVDs) caused by
thrombus, this has sparked an interest in seeking more effective thrombolytic drugs or …

Diverse origins of fibrinolytic enzymes: A comprehensive review

C Hazare, P Bhagwat, S Singh, S Pillai - Heliyon, 2024 - cell.com
Fibrinolytic enzymes cleave fibrin which plays a crucial role in thrombus formation which
otherwise leads to cardiovascular diseases. While different fibrinolytic enzymes have been …

[HTML][HTML] Development and testing of thrombolytics in stroke

D Nikitin, S Choi, J Mican, M Toul, WS Ryu… - Journal of …, 2021 - synapse.koreamed.org
Despite recent advances in recanalization therapy, mechanical thrombectomy will never be
a treatment for every ischemic stroke because access to mechanical thrombectomy is still …

Thrombolytic and anticoagulant efficiencies of purified fibrinolytic enzyme produced from Cochliobolus hawaiiensis under solid‐state fermentation

MA Abu‐Tahon, AM Abdel‐Majeed… - Biotechnology and …, 2023 - Wiley Online Library
Abstract Cochliobolus hawaiiensis Alcorn Assiut University Mycological Centre 8606 was
chosen from the screened 20 fungal species as the potent producer of fibrinolytic enzyme on …

Computational-approach understanding the structure-function prophecy of Fibrinolytic Protease RFEA1 from Bacillus cereus RSA1

C Sharma, A Nigam, R Singh - PeerJ, 2021 - peerj.com
Microbial fibrinolytic proteases are therapeutic enzymes responsible to ameliorate
thrombosis, a fatal cardiac-disorder which effectuates due to excessive fibrin accumulation …

Development of a Methodology Based on Optical Interferometry for Measuring Fibrinolytic Activity

L Liu, N Ma, L Wang, Y Zhang, YZ Wan… - Analytical …, 2024 - ACS Publications
Fibrinolytic activity assay is particularly important for the detection, diagnosis, and treatment
of cardiovascular disease and the development of fibrinolytic drugs. A novel efficacious …

Purification and Characterization of a Novel Fibrinolytic Enzyme from Marine Bacterium Bacillus sp. S-3685 Isolated from the South China Sea

Z Ma, J Elango, J Hao, W Wu - Marine Drugs, 2024 - mdpi.com
A novel fibrinolytic enzyme, BSFE1, was isolated from the marine bacterium Bacillus sp. S-
3685 (GenBank No.: KJ023685) found in the South China Sea. This enzyme, with a …