Altered TDP-43 structure and function: Key insights into aberrant RNA, mitochondrial, and cellular and systemic metabolism in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with
no cure available and limited treatment options. ALS is a highly heterogeneous disease …
no cure available and limited treatment options. ALS is a highly heterogeneous disease …
Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells
L Fan, M Zheng, X Zhou, Y Yu, Y Ning, W Fu… - Journal of Translational …, 2023 - Springer
Background Polyploid giant cancer cells (PGCCs), a specific type of cancer stem cells
(CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy …
(CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy …
[HTML][HTML] VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration
S Argueti-Ostrovsky, S Barel, J Kahn, A Israelson - Biomolecules, 2024 - mdpi.com
Voltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein
that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating …
that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating …
C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD
J Sultana, AMG Ragagnin, S Parakh… - Molecular …, 2024 - Springer
Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72
(C9orf72) gene are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) …
(C9orf72) gene are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) …
Activated Fibroblast Growth Factor Receptor 1 Mitigated Poly-PR–Induced Oxidative Stress and Protein Translational Impairment
T Ito, K Ohuchi, H Kurita, T Murakami… - Biological and …, 2025 - jstage.jst.go.jp
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
selective motor neuron cell death. A GGGGCC hexanucleotide repeat expansion (HRE) …
selective motor neuron cell death. A GGGGCC hexanucleotide repeat expansion (HRE) …
Investigating Adenosine Deaminase and Purine Metabolism in C9orf72 Amyotrophic Lateral Sclerosis
B Hall - 2023 - etheses.whiterose.ac.uk
Background: ALS is a neurodegenerative disorder characterised by the death of motor
neurons (MNs) in the brain stem and spinal cord. The most common genetic mutation …
neurons (MNs) in the brain stem and spinal cord. The most common genetic mutation …