Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Is depression among older adults symptomatically different than younger adults? Is it more
common or chronic or difficult to treat? Is depression in late life more likely to be attributed to …

Abstract Theory predicts that biological processes of aging may contribute to poor mental
health in late life. To test this hypothesis, we evaluated prospective associations between …

Multimorbidity and depression are complex multifactorial conditions with major implications
for older individuals, their families, and healthcare providers. In this scoping review, we …

Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

The network theory conceptualizes mental disorders as complex networks of symptoms
influencing each other by creating feedback loops, leading to a self-sustained syndromic …

Many factors have contributed to rendering frailty an emerging, relevant, and very popular
concept. First, many pandemics that have affected humanity in history, including COVID-19 …

Objectives To examine the six-year prognosis of patients with late-life depression and to
identify prognostic factors of an unfavorable course. Design and Setting The Netherlands …

Background The pathophysiology of late-life depression (LLD) is complex and
heterogeneous, with age-related processes implicated in its pathogenesis. This study …

Background In the absence of one intervention that can cure all patients with major
depressive disorder (MDD), the leading cause of disability worldwide, increased attention …