Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …

Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in developing …

Abstract The recently proposed Research Domain Criteria (RDoC) system defines
psychopathologies as phenomena of multilevel neurobiological existence and assigns them …

Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

Vitamin D deficiency has been estimated to affect roughly 30% to 50% of the global
population and thus labeled as a silent pandemic. In addition to its role in skeletal and …

Depression, plus the accompanying memory impairment, is one of the leading causes of
disability worldwide. Thus, there is a critical need to develop new drugs based on distinct …

Curculigoside (CUR) is the main active component of traditional Chinese medicine
Curculigoorchioides Gaertn (Xianmao in Chinese), which exhibits a variety of …

Background Stress precipitates mood disorders, characterized by a range of symptoms
present in different combinations, suggesting the existence of disease subtypes. Using an …

Stress can predispose to depressive episodes, yet the molecular mechanisms regulating the
transition from the initial stress response to a persistent pathological depressive state remain …