Optimizing lung cancer radiation therapy: a systematic review of multifactorial risk assessment for radiation-induced lung toxicity

R Bensenane, S Helfre, K Cao, M Carton… - Cancer Treatment …, 2024 - Elsevier
Background Radiation therapy (RT) is essential in treating advanced lung cancer, but may
lead to radiation pneumonitis (RP). This systematic review investigates the use of pulmonary …

The emerging role of Artificial Intelligence in proton therapy: A review

LJ Isaksson, F Mastroleo, MG Vincini, G Marvaso… - Critical Reviews in …, 2024 - Elsevier
Artificial intelligence (AI) has made a tremendous impact in the space of healthcare, and
proton therapy is not an exception. Proton therapy has witnessed growing popularity in …

Function-Wise Dual-Omics analysis for radiation pneumonitis prediction in lung cancer patients

B Li, G Ren, W Guo, J Zhang, SK Lam… - Frontiers in …, 2022 - frontiersin.org
Purpose: This study investigates the impact of lung function on radiation pneumonitis
prediction using a dual-omics analysis method. Methods: We retrospectively collected data …

Lung subregion partitioning by incremental dose intervals improves omics-based prediction for acute radiation pneumonitis in non-small-cell lung cancer patients

B Li, X Zheng, J Zhang, S Lam, W Guo, Y Wang, S Cui… - Cancers, 2022 - mdpi.com
Simple Summary Acute radiation pneumonitis (ARP) is one of the common radiation
toxicities in patients with non-small-cell lung cancer (NSCLC) treated by radiotherapy. The …

A deep learning‐based dual‐omics prediction model for radiation pneumonitis

L Bin, T Yuan, S Zhaohui, R Wenting… - Medical …, 2021 - Wiley Online Library
Purpose Radiation pneumonitis (RP) is the main source of toxicity in thoracic radiotherapy.
This study proposed a deep learning‐based dual‐omics model, which aims to improve the …

Metrics of dose to highly ventilated lung are predictive of radiation-induced pneumonitis in lung cancer patients

MJ Flakus, SP Kent, EM Wallat, AE Wuschner… - Radiotherapy and …, 2023 - Elsevier
Purpose To identify metrics of radiation dose delivered to highly ventilated lung that are
predictive of radiation-induced pneumonitis. Methods and Materials A cohort of 90 patients …

Radiation and immune checkpoint inhibitor-mediated pneumonitis risk stratification in patients with locally advanced non-small cell lung cancer: role of functional lung …

HMT Thomas, DS Hippe, P Forouzannezhad… - Discover Oncology, 2022 - Springer
Background Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI)
therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary …

Radiation-induced Hounsfield unit change correlates with dynamic CT perfusion better than 4DCT-based ventilation measures in a novel-swine model

AE Wuschner, EM Wallat, MJ Flakus… - Scientific reports, 2021 - nature.com
To analyze radiation induced changes in Hounsfield units and determine their correlation
with changes in perfusion and ventilation. Additionally, to compare the post-RT changes in …

New developments in locally advanced nonsmall cell lung cancer

RM Huber, D Kauffmann-Guerrero… - European …, 2021 - Eur Respiratory Soc
Locally advanced nonsmall cell lung cancer, due to its varying prognosis, is grouped
according to TNM stage IIIA, IIIB and IIIC. Developments over the last 3 years have been …

Prediction of radiation pneumonitis with machine learning using 4D-CT based dose-function features

Y Katsuta, N Kadoya, S Mouri, S Tanaka… - Journal of Radiation …, 2022 - academic.oup.com
In this article, we highlight the fundamental importance of the simultaneous use of dose-
volume histogram (DVH) and dose-function histogram (DFH) features based on functional …