Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Although it is a relatively rare disease, primarily found in the Caucasian population, uveal
melanoma is the most common primary intraocular tumor in adults with a mean age …

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs
are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which …

The BRCA1‐associated protein‐1 (BAP1) tumor predisposition syndrome (BAP1‐TPDS) is a
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …

BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for
a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical …

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and
accounts for about 5% of all melanomas. Primary disease can be effectively controlled by …

A family history of melanoma greatly increases the risk of developing cutaneous melanoma,
a highly aggressive skin cancer whose incidence has been steadily increasing worldwide …

Uveal melanoma (UM) is the most common malignant eye tumor in adults affecting~ 7,000
individuals per year worldwide. UM is a rare subtype of melanoma with distinct clinical and …

Purpose The aim of this study was to review the genetics, epidemiology, clinical findings,
and management of BRCA1-associated protein-1 (BAP1) cancer predisposition syndrome …

Uveal melanoma (UM) is a rare tumour with a high propensity to metastasize. Although no
effective treatment for metastases yet exists, prognostication in UM is relevant for patient …