Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

The number of membrane protein structures in the Protein Data Bank is becoming significant
and growing. Here, the transmembrane domain structures of the helical membrane proteins …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

Studying biomolecules at atomic resolution in their native environment is the ultimate aim of
structural biology. We investigated the bacterial type IV secretion system core complex …

Structure determination of membrane proteins in native cellular membranes is critical to
precisely reveal their structures in physiological conditions. However, it remains challenging …

Membrane proteins present a challenge for structural biology. In this article, we review some
of the recent developments that advance the application of NMR to membrane proteins, with …

Building on a decade of continuous advances of the community, the recent development of
very fast (60 kHz and above) magic-angle spinning (MAS) probes has revolutionised the …

Membrane proteins mediate flow of molecules, signals, and energy between cells and
intracellular compartments. Understanding membrane protein function requires a detailed …

For a long time, solid-state nuclear magnetic resonance (ssNMR) has been employed to
study complex biomolecular systems at the detailed chemical, structural, or dynamic level …