Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …

Bacterial colonization of the gut shapes both the local and the systemic immune response
and is implicated in the modulation of immunity in both healthy and disease states. Recently …

Background & Aims We analyzed DNA methylation patterns and transcriptomes of primary
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …

Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …

Background The interplay of epigenetic processes and the intestinal microbiota may play an
important role in intestinal development and homeostasis. Previous studies have …

Objective Human intestinal epithelial organoids (IEOs) are increasingly being recognised as
a highly promising translational research tool. However, our understanding of their …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …

Recent advances in our understanding of the pathogenesis of inflammatory bowel disease
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …

Genetic variants in the DNA methyltransferase 3 A (DNMT3A) locus have been associated
with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery …

Objective The epithelial layer of the GI tract is equipped with innate immune receptors to
sense invading pathogens. Dysregulation in innate immune signalling pathways is …