Detection of Aβ monomers and oligomers: early diagnosis of Alzheimer's disease
Y Zhou, L Liu, Y Hao, M Xu - Chemistry–An Asian Journal, 2016 - Wiley Online Library
Abstract Alzheimer's disease (AD), as the most common progressive neurodegenerative
disorder, is pathologically characterized by deposition of extracellular plaque composed of …
disorder, is pathologically characterized by deposition of extracellular plaque composed of …
How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1−40
B Schwarze, D Huster - Macromolecular Bioscience, 2023 - Wiley Online Library
Amyloid fibrils represent the structural endpoint on the energetic (mis) folding landscape of
very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark …
very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark …
Cell-membrane-mimicking lipid-coated nanoparticles confer Raman enhancement to membrane proteins and reveal membrane-attached amyloid-β conformation
Identifying the structures of membrane bound proteins is critical to understanding their
function in healthy and diseased states. We introduce a surface enhanced Raman …
function in healthy and diseased states. We introduce a surface enhanced Raman …
An early folding contact between Phe19 and Leu34 is critical for amyloid-β oligomer toxicity
Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically
toxic. Here we examine this view by perturbing an early folding contact between Phe19 and …
toxic. Here we examine this view by perturbing an early folding contact between Phe19 and …
Major reaction coordinates linking transient amyloid-β oligomers to fibrils measured at atomic level
The structural underpinnings for the higher toxicity of the oligomeric intermediates of
amyloidogenic peptides, compared to the mature fibrils, remain unknown at present. The …
amyloidogenic peptides, compared to the mature fibrils, remain unknown at present. The …
Altered membrane mechanics provides a receptor‐independent pathway for serotonin action
Serotonin, an important signaling molecule in humans, has an unexpectedly high lipid
membrane affinity. The significance of this finding has evoked considerable speculation …
membrane affinity. The significance of this finding has evoked considerable speculation …
Ordered and Disordered Segments of Amyloid Beta Drive Sequential Steps of the Toxic Pathway
Pathological amyloid deposits of two intrinsically disordered proteins (IDPs) namely, a-
synuclein (a-syn) and tau, are found in the intracellular Lewy bodies in Parkinson's disease …
synuclein (a-syn) and tau, are found in the intracellular Lewy bodies in Parkinson's disease …
A Toxicogenic Interaction between Intracellular Amyloid-β and Apolipoprotein-E
Alzheimer's disease (AD) is associated with the aggregation of amyloid β (Aβ) and tau
proteins. Why ApoE variants are significant genetic risk factors remains a major unsolved …
proteins. Why ApoE variants are significant genetic risk factors remains a major unsolved …
[HTML][HTML] Aggregation-induced conformation changes dictate islet amyloid polypeptide (IAPP) membrane affinity
Islet amyloid polypeptide (IAPP) is a 37 residue intrinsically disordered protein whose
aggregation is associated with Type II diabetes. Like most amyloids, it appears that the …
aggregation is associated with Type II diabetes. Like most amyloids, it appears that the …
β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization
Alzheimer's disease is the most common form of senile dementia in the world, and amyloid β
peptide1-42 (Aβ 1-42) is one of its two principal biological hallmarks. While interactome …
peptide1-42 (Aβ 1-42) is one of its two principal biological hallmarks. While interactome …