Protein disulfide isomerase: a promising target for cancer therapy
S Xu, S Sankar, N Neamati - Drug discovery today, 2014 - Elsevier
Highlights•PDI is an important oxidase, reductase, isomerase and molecular
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …
The unfolded protein response and the role of protein disulfide isomerase in neurodegeneration
The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons
and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite …
and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite …
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA
binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons and glia …
binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons and glia …
Novel roles for protein disulphide isomerase in disease states: a double edged sword?
Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic
reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have …
reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have …
Protein folding alterations in amyotrophic lateral sclerosis
Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …
ISG15 counteracts Listeria monocytogenes infection
L Radoshevich, F Impens, D Ribet, JJ Quereda… - Elife, 2015 - elifesciences.org
ISG15 is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity. The
role of ISG15 during bacterial infection remains elusive. We show that ISG15 expression in …
role of ISG15 during bacterial infection remains elusive. We show that ISG15 expression in …
The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma
G Tufo, AWE Jones, Z Wang, J Hamelin… - Cell Death & …, 2014 - nature.com
Intrinsic and acquired chemoresistance are frequent causes of cancer eradication failure.
Thus, long-term cis-diaminedichloroplatine (II)(CDDP) or cisplatin treatment is known to …
Thus, long-term cis-diaminedichloroplatine (II)(CDDP) or cisplatin treatment is known to …
The role of reticulons in neurodegenerative diseases
V Chiurchiu, M Maccarrone, A Orlacchio - Neuromolecular medicine, 2014 - Springer
Reticulons (RTNs) are a group of membrane-associated proteins mainly responsible for
shaping the tubular endoplasmic reticulum network, membrane trafficking, inhibition of …
shaping the tubular endoplasmic reticulum network, membrane trafficking, inhibition of …
Activation of PERK-eIF2α-ATF4 pathway contributes to diabetic hepatotoxicity: attenuation of ER stress by Morin
Hyperglycemia associated ER stress has been found as a critical contributor in the
pathogenesis of type 2 diabetes mellitus. However, reports regarding molecular …
pathogenesis of type 2 diabetes mellitus. However, reports regarding molecular …
Membrane-shaping disorders: a common pathway in axon degeneration
Neurons with long projections are particularly liable to damage, which is reflected by a large
group of hereditary neurodegenerative disorders that primarily affect these neurons. In the …
group of hereditary neurodegenerative disorders that primarily affect these neurons. In the …