Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

Highly regulated activation of B cells is required for the production of specific antibodies
necessary to provide protection from pathogen infection. This process is initiated by specific …

CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and
regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell-and …

Bioorthogonal deprotections are readily used to control biological function in a cell-specific
manner. To further improve the spatial resolution of these reactions, we here present a …

Natural killer T (NKT) cells are a subset of T lymphocytes that share surface markers and
functional characteristics with both conventional T lymphocytes and natural killer cells. Most …

Vα24-invariant natural killer T cells (NKTs) are strictly CD1d-restricted, and CD1d
expression has been found in several types of leukemia and lymphoma as well as in brain …

In spite of their relatively limited antigen receptor repertoire, CD1d-restricted NKT cells
recognize a surprisingly diverse range of lipid and glycolipid antigens. Recent studies of …

The light-harvesting complexes of photosystem I and II (Lhcas and Lhcbs) of plants display a
high structural homology and similar pigment content and organization. Yet, the …