The local microenvironment, or niche, of a cancer cell plays important roles in cancer
development. A major component of the niche is the extracellular matrix (ECM), a complex …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing
both biophysical and biochemical cues that are important regulators of cell proliferation …

Completion of genome sequences for many organisms allows a reasonably complete
definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core …

Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as
developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has …

Fibronectin (FN) is a multidomain protein with the ability to bind simultaneously to cell
surface receptors, collagen, proteoglycans, and other FN molecules. Many of these domains …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

This review deals with the large and pleiotropic superfamily of cadherins and its molecular
evolution. We compiled literature data and an in-depth phylogenetic analysis of more than …

Introduction: Numerous clinical and pre-clinical studies have provided ample evidence
supporting that the tumor microenvironment plays a significant role during breast cancer …