PPARs at the crossroads of lipid signaling and inflammation

W Wahli, L Michalik - Trends in Endocrinology & Metabolism, 2012 - cell.com
Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …

Physiological functions of peroxisome proliferator-activated receptor β

JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

A Giordano, I Murano, E Mondini, J Perugini… - Journal of lipid …, 2013 - ASBMB
We previously suggested that, in obese animals and humans, white adipose tissue
inflammation results from the death of hypertrophic adipocytes; these are then cleared by …

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

YS Lee, MS Park, JS Choung, SS Kim, HH Oh, CS Choi… - Diabetologia, 2012 - Springer
Aims/hypothesis Obesity and insulin resistance are associated with low-grade chronic
inflammation. Glucagon-like peptide-1 (GLP-1) is known to reduce insulin resistance. We …

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

KD Wagner, N Wagner - Pharmacology & therapeutics, 2010 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors. They function as
ligand activated transcription factors. They exist in three isoforms, PPARα, PPARβ (formerly …

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading …

E Barroso, R Rodríguez-Calvo, L Serrano-Marco… - …, 2011 - academic.oup.com
Metabolic syndrome-associated dyslipidemia is mainly initiated by hepatic overproduction of
the plasma lipoproteins carrying triglycerides. Here we examined the effects of the …

The two-way immunotoxicity in native fish induced by exudates of Microcystis aeruginosa: Immunostimulation and immunosuppression

S Zhao, X Chang, J Li, Y Zhu, X Pan, Z Hua… - Journal of Hazardous …, 2024 - Elsevier
Secondary metabolites of cyanobacterial blooms have caused serious risks to aquatic
animals. The immune system is an important barrier for fish against pollutants in aquatic …

Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome

A Jungbauer, S Medjakovic - Maturitas, 2012 - Elsevier
Obesity and metabolic syndrome are increasing global health problems. In addition to the
malnutrition of a sedentary lifestyle, high calorie intake leads to obesity with many negative …

PPARβ/δ: a key therapeutic target in metabolic disorders

X Palomer, E Barroso, J Pizarro-Delgado… - International journal of …, 2018 - mdpi.com
Research in recent years on peroxisome proliferator-activated receptor (PPAR) β/δ indicates
that it plays a key role in the maintenance of energy homeostasis, both at the cellular level …

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

T Hu, Q Lin, T Guo, T Yang, W Zhou, X Deng… - Carbohydrate …, 2018 - Elsevier
In the present study, the anti-inflammatory function of Phellinus linteus polysaccharide (PLP)
was investigated in animal and cell inflammation models, and the anti-inflammatory …