Pregnancy is a unique type of immunological process. Healthy pregnancy is associated with
a series of inflammatory events: implantation (inflammation), gestation (anti-inflammation) …

Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental
blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries …

The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of
proteinuria and hypertension, is associated with significant morbidity and mortality to both …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Wingless ligands, a family of secreted proteins, are critically involved in organ development
and tissue homeostasis by ensuring balanced rates of stem cell proliferation, cell death and …

Oxygen homeostasis represents an important organizing principle for human development
and physiology. The essential requirement for oxidative phosphorylation to generate ATP is …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

During early pregnancy, placentation occurs in a relatively hypoxic environment that is
essential for appropriate embryonic development. Intervillous blood flow increases around …

Pre-eclampsia is more than pregnancy induced hypertension. The emerging view described
in this presentation is that pre-eclampsia is secondary to the interactions of reduced …