The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …

The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal
neuron degeneration, and intraneuronal and intraneuritic proteinaceous inclusions named …

Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to
presynaptic terminals. Due to elevated conformational plasticity, which can be affected by …

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

Evidence from both preclinical and clinical studies suggest the importance of zinc
homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is …

Abstract Parkinson's disease (PD), the most common neurodegenerative movement
disorder, is characterized by the progressive loss of nigral dopamine neurons. The …

Synapsins are a family of synaptic vesicle proteins that are important for neurotransmitter
release. Here we have used triple knock-out (TKO) mice lacking all three synapsin genes to …