Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant
organs. At primary diagnosis, prognostic markers are used to assess whether the transition …

Background Breast cancer is the most common cancer in women worldwide, with a great
diversity in outcomes among individual patients. The ability to accurately predict a breast …

Purpose Current immunohistochemical (IHC)-based definitions of luminal A and B breast
cancers are imperfect when compared with multigene expression-based assays. In this …

Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic …

Background Genome-wide measures of gene expression can identify patterns of gene
activity that subclassify tumours and might provide a better means than is currently available …

The development of an oncogenic state is a complex process involving the accumulation of
multiple independent mutations that lead to deregulation of cell signalling pathways central …

Background Validation of a novel gene expression signature in independent data sets is a
critical step in the development of a clinically useful test for cancer patient risk-stratification …

Motivation: Classification and feature selection of genomics or transcriptomics data is often
hampered by the large number of features as compared with the small number of samples …

Profiling breast cancer with expression arrays has become common, and it has been
suggested that the results from early studies will lead to understanding of the molecular …

Microarray profiling of invasive breast carcinomas has identified five distinct subtypes of
tumors (luminal A, luminal B, normal breast-like, HER2 overexpressing, and basal-like) that …