Aneuploidy and complex genomic rearrangements in cancer evolution
TM Baker, S Waise, M Tarabichi, P Van Loo - Nature cancer, 2024 - nature.com
Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …
tumors. They range from simple copy number gains and losses to the shattering and …
Multiomics network medicine approaches to precision medicine and therapeutics in cardiovascular diseases
Cardiovascular diseases (CVD) are the leading cause of death worldwide and display
complex phenotypic heterogeneity caused by many convergent processes, including …
complex phenotypic heterogeneity caused by many convergent processes, including …
[HTML][HTML] Ovarian cancer mutational processes drive site-specific immune evasion
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability,,–
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
Live birth of chimeric monkey with high contribution from embryonic stem cells
A formal demonstration that mammalian pluripotent stem cells possess preimplantation
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …
[HTML][HTML] Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …
[HTML][HTML] Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells
Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal
instability and result in heterogeneous cancer cell populations with distinct phenotypes …
instability and result in heterogeneous cancer cell populations with distinct phenotypes …
[HTML][HTML] Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity
TBK Watkins, EC Colliver, MR Huska… - PLoS computational …, 2023 - journals.plos.org
Most computational methods that infer somatic copy number alterations (SCNAs) from bulk
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
Targeting chromosomal instability in patients with cancer
DH Al-Rawi, E Lettera, J Li, M DiBona… - Nature Reviews Clinical …, 2024 - nature.com
Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …
[HTML][HTML] Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies
JR Andrade, AD Gallagher, J Maharaj… - Chromosome …, 2023 - Springer
Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …
[HTML][HTML] Multi-scale characterisation of homologous recombination deficiency in breast cancer
Background Homologous recombination is a robust, broadly error-free mechanism of double-
strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying …
strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying …