Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only
affects acute morbidity and mortality, but also a patient's long-term prognosis. In this …

SARS-CoV2 infection can impact all organs structurally and functionally. Persisting
symptoms in patients recovering from coronavirus disease 2019 (COVID-19) are common …

Background Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney
injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney …

INTRODUCTION Acute kidney injury and chronic kidney disease (CKD) are common in
hospitalized patients. To inform clinical decision making, more accurate information …

Incomplete repair after acute kidney injury can lead to development of chronic kidney
disease. To define the mechanism of this response, we compared mice subjected to …

Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs,
including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1+) cells are …

Background: Prior studies associating acute kidney injury (AKI) with more rapid subsequent
loss of kidney function had methodological limitations, including inadequate control for …

Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with
high in-hospital mortality, increased long-term mortality postdischarge, and subsequent …

SA-AKI is a common condition that can involve disturbances in the RAS, particularly the
canonical angiotensin-converting enzyme (ACE) angiotensin-II (Ang II)/angiotensin II …

Since the description ischuria renalis by William Heberden (1), AKI has remained a
prominent complication of critical illness. Beyond KRT, treatment has been limited by the …