Pulmonary fibrosis (PF) is a chronic and relentlessly progressive interstitial lung disease in
which the accumulation of fibroblasts and extracellular matrix (ECM) induces the destruction …

Bone tissue engineering has been becoming a promising strategy for surgical bone repair,
but the risk of infection during trauma repair remains a problematic health concern …

Adult lung resident stem/progenitor cells, including P63+ progenitor cells, have
demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here …

Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic
reticulum stress (ERS) and mitochondria dysfunction, which lead to oxidative stress-induced …

Host defence peptides (HDPs), also known as antimicrobial peptides, are naturally occurring
polypeptides (~ 12-50 residues) composed of cationic and hydrophobic amino acids that …

A broad spectrum of lethal kidney diseases involves the irreversible destruction of the
tubular structures, leading to renal function loss. Following injury, a spectrum of tissue …

Objectives The high mortality of severe 2019 novel coronavirus disease (COVID‐19) cases
is mainly caused by acute respiratory distress syndrome (ARDS), which is characterized by …

Background Functional alveolar regeneration is essential for the restoration of normal lung
homeostasis after acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) …

A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate
CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the …

Objectives Chronic obstructive pulmonary disease (COPD) is characterized by irreversible
lung tissue damage including chronic bronchitis and emphysema, which could further …