Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology

CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …

[HTML][HTML] Polygenic scores for social science: Clarification, consensus, and controversy

CH Burt - The Behavioral and brain sciences, 2023 - ncbi.nlm.nih.gov
In this response, I focus on clarifying my arguments, highlighting consensus, and addressing
competing views about the utility of PGSs for social science. I also discuss an assortment of …

[HTML][HTML] Vertical pleiotropy explains the heritability of social science traits

C Xia, WD Hill - The Behavioral and brain sciences, 2023 - ncbi.nlm.nih.gov
We contend that social science variables are the product of multiple partly heritable traits.
Genetic associations with socio-economic status (SES) may differ across populations, but …

[HTML][HTML] Taking a lifespan approach to polygenic scores

E Freitag, CM Kelsey - The Behavioral and brain sciences, 2023 - ncbi.nlm.nih.gov
This commentary is a call to action for researchers to create and use genome-wide
association studies (GWASs) with previously missed age groups (eg, infancy, elderly), which …

The failure of gene-centrism.

E Archer, CJ Lavie - Behavioral & Brain Sciences, 2023 - search.ebscohost.com
Abstract" Challenging the utility of polygenic scores for social science" is a compelling but
limited critique. Phenotypic development is sensitive to both initial conditions and all …

Social scientists would do well to steer clear of polygenic scores

D Curtis - Behavioral and Brain Sciences, 2023 - discovery.ucl.ac.uk
The problems with polygenic scores (PGSs) have been understated. The fact that they are
ancestry-specific means that biases related to sociodemographic factors would be …

GWASs and polygenic scores inherit all the old problems of heritability estimates.

S Sarkar - Behavioral & Brain Sciences, 2023 - search.ebscohost.com
Polygenic score (PGS) computations assume an additive model of gene action because
associations between phenotypes and alleles at different loci are compounded, ignoring …

Beyond a Shared History: A Biosocial Perspective on Sociogenomics and Racism in Germany

MAN Aikins, YE Willems, D Fraemke… - KZfSS Kölner Zeitschrift …, 2024 - Springer
Recent advances in sociogenomics offer new opportunities to integrate genetic and
epigenetic measures into social science research on human lifespan development. Now …

“Ethical Responsibility Very Often Gets Drowned Out”: A Qualitative Interview Study of Genome Scientists' and ELSI Scholars' Perspectives on the Role and Relevance …

DO Martschenko, A Grannuci, MK Cho - AJOB Empirical Bioethics, 2024 - Taylor & Francis
Abstract Background Genome scientists and Ethical, Legal, and Social Implications of
genetics (ELSI) scholars commonly inhabit distinct research cultures–utilizing different …

[PDF][PDF] Polygenic scores ignore development and epigenetics, dramatically reducing their value.

DS Moore - Behavioral & Brain Sciences, 2023 - drive.google.com
Polygenic scores cannot elucidate the mechanisms that produce behavioral phenotypes
(including “intelligence”). Therefore, they are unlikely to yield helpful interventions …