Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

Ageing is characterized by the development of persistent pro-inflammatory responses that
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …

Circular RNAs (circRNAs) have gained growing attention in participating in various
biological processes and referring to multiply kinds of diseases. Although differentially …

Synapses are essential for transmitting, processing, and storing information, all of which
decline in aging and Alzheimer's disease (AD). Because synapse loss only partially …

Background The necessity of including both males and females in molecular neuroscience
research is now well understood. However, there is relatively limited basic biological data on …

Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

The past two decades have seen remarkable progress in our understanding of the
multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also …

Insulin-like growth factor (IGF)-1 is an important neurotrophic hormone. Deficiency of this
hormone has been reported to influence the genesis of cognitive impairment and dementia …