Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …

Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …

Genomic studies in age-related macular degeneration (AMD) have identified genetic
variants that account for the majority of AMD risk. An important next step is to understand the …

Dysregulation of the alternative pathway (AP) of the complement system is a significant
contributor to age-related macular degeneration (AMD), a primary cause of irreversible …

Purpose To examine disease progression in age-related macular degeneration (AMD) at 2
distinct stages, progression to geographic atrophy (GA) versus GA expansion, by …

To effectively reduce vision loss due to age-related macular generation (AMD) on a global
scale, knowledge of its genetic architecture in diverse populations is necessary. A critical …

Aging is associated with a broad range of visual impairments that can have dramatic
consequences on the quality of life of those impacted. These changes are driven by a …

Advanced age is the most established risk factor for developing age-related macular
degeneration (AMD), one of the leading causes of visual impairment in the elderly, in …

Importance Age-related macular degeneration (AMD) is a common cause of irreversible
vision loss among individuals older than 50 years. Although considerable advances have …