Allergen immunotherapy is a form of therapeutic vaccination for established IgE-mediated
hypersensitivity to common allergen sources such as pollens, house dust mites and the …

Allergen-specific immunotherapy has been carried out for almost a century and remains one
of the few antigen-specific treatments for inflammatory diseases. The mechanisms by which …

Specific immune suppression and induction of tolerance are essential processes in the
regulation and circumvention of immune defence. The balance between allergen‐specific …

The induction of allergen-specific anergy in peripheral T cells represents a key step in
specific immunotherapy (SIT). Here we demonstrate that the anergic state results from …

Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible
individuals. Both naturally occurring CD4+ CD25+ regulatory T cells and inducible …

Allergy is a Th2‐mediated disease that involves the formation of specific IgE antibodies
against innocuous environmental substances. The prevalence of allergic diseases has …

Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …

Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely
allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence …

Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

High dose bee venom exposure in beekeepers by natural bee stings represents a model to
understand mechanisms of T cell tolerance to allergens in healthy individuals. Continuous …