Antimicrobial activity of lactones
M Mazur, D Masłowiec - Antibiotics, 2022 - mdpi.com
The development of bacterial resistance to antibiotics and the consequent lack of effective
therapy is one of the biggest problems in modern medicine. A consequence of these …
therapy is one of the biggest problems in modern medicine. A consequence of these …
Assessment of azithromycin as an anticancer agent for treatment of imatinib sensitive and resistant CML cells
T Ozkan, Y Hekmatshoar, AZ Karabay, A Koc… - Leukemia Research, 2021 - Elsevier
Abstract Introduction Chronic Myeloid Leukemia (CML) is a hematological disease which is
characterized by the presence of BCR-ABL fusion protein. Imatinib (IMA), a tyrosine kinase …
characterized by the presence of BCR-ABL fusion protein. Imatinib (IMA), a tyrosine kinase …
α-Solanine inhibits proliferation, invasion, and migration, and induces apoptosis in human choriocarcinoma JEG-3 cells in vitro and in vivo
T Gu, W Yuan, C Li, Z Chen, Y Wen, Q Zheng, Q Yang… - Toxins, 2021 - mdpi.com
α-Solanine, a bioactive compound mainly found in potato, exhibits anti-cancer activity
towards multiple cancer cells. However, its effects on human choriocarcinoma have not …
towards multiple cancer cells. However, its effects on human choriocarcinoma have not …
The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer …
SF Xing, LH Liu, ML Zu, XF Ding, WY Cui… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Gypenosides are major constituents in Gynostemma
pentaphyllum (Thunb.) Makino. Previous studies have shown that gypenosides isolated from …
pentaphyllum (Thunb.) Makino. Previous studies have shown that gypenosides isolated from …
Selenocystine inhibits JEG-3 cell growth in vitro and in vivo by triggering oxidative damage-mediated S-phase arrest and apoptosis
M Zhao, Y Hou, X Fu, D Li, J Sun, X Fu… - Journal of Cancer …, 2018 - journals.lww.com
Background: Selenocystine (SeC) is a nutritionally available selenoamino acid presenting
novel anticancer potential against human cancers. However, neither the effects nor …
novel anticancer potential against human cancers. However, neither the effects nor …
Preparation of enantiomeric β-(2′, 5′-dimethylphenyl) bromolactones, their antiproliferative activity and effect on biological membranes
W Gładkowski, A Włoch, A Pawlak, A Sysak… - Molecules, 2018 - mdpi.com
Three novel enantiomeric pairs of bromolactones possesing a 2, 5-dimethylphenyl
substituent at the β-position of the lactone ring have been synthesized from corresponding …
substituent at the β-position of the lactone ring have been synthesized from corresponding …
Enantiomeric trans β-aryl-δ-iodo-γ-lactones derived from 2, 5-dimethylbenzaldehyde induce apoptosis in canine lymphoma cell lines by downregulation of anti …
A Pawlak, W Gładkowski, J Kutkowska, M Mazur… - Bioorganic & Medicinal …, 2018 - Elsevier
For many years, studies focused on developing new natural or synthetic compounds with
antineoplastic activity have attracted the attention of researchers. An interesting group of …
antineoplastic activity have attracted the attention of researchers. An interesting group of …
Some 2‐[4‐(1H‐benzimidazol‐1‐yl) phenyl]‐1H‐benzimidazole derivatives overcome imatinib resistance by induction of apoptosis and reduction of P‐glycoprotein …
Y Hekmatshoar, T Ozkan, M Alp… - Chemical Biology & …, 2023 - Wiley Online Library
Imatinib (IMA) is a tyrosine kinase inhibitor (TKI) introduced for the chronic myeloid leukemia
(CML) therapy. Emergence of IMA resistance leads to the relapse and failure in CML …
(CML) therapy. Emergence of IMA resistance leads to the relapse and failure in CML …
Regio-and enantioselective microbial hydroxylation and evaluation of cytotoxic activity of β-cyclocitral-derived halolactones
M Mazur, W Gładkowski, VG Srček, K Radošević… - PLoS …, 2017 - journals.plos.org
Three β-cyclocitral-derived halolactones, which exhibit antifeedant activity towards storage
product pests, were subjected to microbial transformation processes. Among the thirty tested …
product pests, were subjected to microbial transformation processes. Among the thirty tested …
Biotechnological approach for the production of enantiomeric hydroxylactones derived from benzaldehyde and evaluation of their cytotoxic activity
M Mazur, A Kudrynska, A Pawlak, B Hernandez-Suarez… - Catalysts, 2020 - mdpi.com
The β-aryl-δ-halo-γ-lactones are known for their antiproliferative activity towards numerous
cancer cell lines. The aim of this study was to obtain in the biotransformation process new β …
cancer cell lines. The aim of this study was to obtain in the biotransformation process new β …