Late-stage C–H functionalization of azines

CM Josephitis, HMH Nguyen, A McNally - Chemical reviews, 2023 - ACS Publications
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

Visible light-induced transition metal catalysis

KPS Cheung, S Sarkar, V Gevorgyan - Chemical reviews, 2021 - ACS Publications
In recent years, visible light-induced transition metal catalysis has emerged as a new
paradigm in organic photocatalysis, which has led to the discovery of unprecedented …

Photodecarboxylative C–H Alkylation of Azauracils with N-(Acyloxy)phthalimides

SP Panda, SK Hota, R Dash, L Roy, S Murarka - Organic Letters, 2023 - ACS Publications
We disclose a transition-metal-free NaI/PPh3-mediated direct C–H alkylation of azauracils
using N-(acyloxy) pthalimides (NHPIs) as readily available alkyl surrogates under visible …

Visible-light-induced metal-free coupling of C (sp 3)–H sources with heteroarenes

A Ghosh, P Pyne, S Ghosh, D Ghosh, S Majumder… - Green …, 2022 - pubs.rsc.org
Development of an efficient, mild, economically viable, and green method for the
construction of a Csp2–Csp3 bond via coupling between a saturated hydrocarbon [(Csp3) …

Photoinduced Electron Donor–Acceptor Complex-Mediated Radical Cascade Involving N-(Acyloxy)phthalimides: Synthesis of Tetrahydroquinolines

SK Hota, SP Panda, S Das, SK Mahapatra… - The Journal of …, 2023 - ACS Publications
We conceptualized a novel disconnection approach for the synthesis of fused
tetrahydroquinolines that exploits a visible light-mediated radical (4+ 2) annulation between …

Decarboxylative N-alkylation of azoles through visible-light-mediated organophotoredox catalysis

R Kobayashi, S Shibutani, K Nagao, Z Ikeda… - Organic …, 2021 - ACS Publications
An organophotoredox-catalyzed decarboxylative cross-coupling between azole
nucleophiles and aliphatic carboxylic acid-derived redox-active esters is demonstrated. This …

An organophotoredox-catalyzed redox-neutral cascade involving N-(acyloxy) phthalimides and allenamides: synthesis of indoles

S Das, A Azim, SK Hota, SP Panda… - Chemical …, 2021 - pubs.rsc.org
An organophotoredox-catalyzed radical cascade of allenamides and alkyl N-(acyloxy)
phthalimides for the synthesis of indoles is documented. The method features mild and …

Synthesis of secondary trifluoromethylated alkyl bromides using 2-bromo-3, 3, 3-trifluoropropene as a radical acceptor

P Guo, M Tao, WW Xu, AJ Wang, W Li, Q Yao… - Organic …, 2022 - ACS Publications
Herein, the first example using commercially available 2-bromo-3, 3, 3-trifluoropropene
(BTP) as a radical acceptor has been reported. Taking advantage of this strategy, a wide …

Organophotoredox‐Catalyzed Late‐Stage Functionalization of Heterocycles

S Kumar Hota, D Jinan… - Asian Journal of …, 2021 - Wiley Online Library
In the last decade, visible light photoredox catalysis promoting radical‐based organic
transformations has received enormous synthetic applicability, as they allow unfolding of site …

Late‐Stage Functionalisation of Pyridine‐Containing Bioactive Molecules: Recent Strategies and Perspectives

M Failla, GW Lombardo, P Orlando… - European Journal of …, 2023 - Wiley Online Library
Abstract Late‐Stage Functionalisation (LSF) is an innovative technique that has been
successfully applied to the C− H diversification of pharmaceuticals. However, LSF of the …