From isles of Königsberg to islets of Langerhans: examining the function of the endocrine pancreas through network science
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …
The role of cAMP in beta cell stimulus–secretion and intercellular coupling
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …
nutrients, and impaired insulin secretion plays a central role in development of diabetes …
Assessing different temporal scales of calcium dynamics in networks of beta cell populations
Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent
oscillations of membrane potential and intracellular calcium concentration that presumably …
oscillations of membrane potential and intracellular calcium concentration that presumably …
Determinants and dynamics of pancreatic islet architecture
MT Adams, B Blum - Islets, 2022 - Taylor & Francis
The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …
[HTML][HTML] Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices
Many details of glucose-stimulated intracellular calcium changes in β cells during activation,
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …
The effect of forskolin and the role of Epac2A during activation, activity, and deactivation of beta cell networks
M Skelin Klemen, J Dolenšek… - Frontiers in …, 2023 - frontiersin.org
Beta cells couple stimulation by glucose with insulin secretion and impairments in this
coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) …
coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) …
NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis
M Šterk, L Križančić Bombek… - PLoS computational …, 2021 - journals.plos.org
NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-
stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for …
stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for …
Mitochondrial dysfunction in pancreatic alpha and beta cells associated with type 2 diabetes mellitus
Type 2 diabetes mellitus is a complex multifactorial disease of epidemic proportions. It
involves genetic and lifestyle factors that lead to dysregulations in hormone secretion and …
involves genetic and lifestyle factors that lead to dysregulations in hormone secretion and …
Multilevel synchronization of human β-cells networks
β-cells within the endocrine pancreas are fundamental for glucose, lipid and protein
homeostasis. Gap junctions between cells constitute the primary coupling mechanism …
homeostasis. Gap junctions between cells constitute the primary coupling mechanism …
Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model …
Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via
different communication pathways. Their oscillatory activity manifests itself on multiple …
different communication pathways. Their oscillatory activity manifests itself on multiple …