Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …

Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in
extent between patients. It is unclear whether inter-individual variability in glutamate is …

Ultra-high field proton magnetic resonance spectroscopy (1 HMRS) offers a unique
opportunity to measure the concentration of neurometabolites implicated in psychosis (PSY) …

Abstract N-acetyl-aspartate (NAA) is a readily measured marker of neuronal metabolism.
Previous analyses in schizophrenia have shown NAA levels are low in frontal, temporal and …

Brain temperature determines not only an individual's cognitive functionality but also the
prognosis and mortality rates of many brain diseases. More specifically, brain temperature …