Through the exploitation of several conventional strategies in subdisciplines of chemistry
and the molecular sciences became challenging due to toxic chemicals in last few years. As …

Abstract Poly (ADP-ribose) polymerase (PARP) is considered an essential component in
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …

Methods have been developed for the stereocontrolled synthesis of bicyclic diaza [3.3. 0]
octane carboxylic acids as possible isosteres of piperazine 2 S-carboxylic acid. In the first …

Piperazine is a privileged moiety that is a structural part of many clinical drugs. Piperazine-
based scaffolds have attracted the attention of pharmaceutical and medicinal scientists to …

As an important epigenetic regulator, histone lysine specific demethylase 1 (LSD1) has
become an attractive target for the discovery of anticancer agents. In this work, a series of …

To discover novel carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors for cancer treatment, a
series of 4-{4-[(hydroxyimino) methyl] piperazin-1-yl} benzenesulfonamides were designed …

Novel analogs of quinoline and isoindoline containing various heterocycles, such as
tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR …

Lung adenocarcinoma is regarded as the most common form of lung cancer, per the latest
epidemiological data. The combined efforts from chemotherapy and radiotherapy have done …

Abstract Novel pyrrolo [2, 3-d] pyrimidine-based analogues were designed, synthesized,
and evaluated for their ability to inhibit the α-amylase enzyme in order to treat diabetes. In …

This rational pursuit led to the identification of a novel sulfonamide derivative as a potent anti-
lung cancer (LC) compound. Considering these results, we synthesized 38 novel …